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The Sanctuary of the Madonna delle Grazie is a late 15th-century Catholic church. During the 17th century, the Orsini family financed the interior decoration. Restoration work on the façade was necessary following the earthquake of 1705. In 1931, the bell tower was built. The statue of Our Lady of Grace with the child on her lap dates from around 1490.

The sanctuary of the Madonna di Caravaggio dates back to the 17th century. As early as 1645, a cross was placed on the site of the present shrine, the destination of an annual procession of the inhabitants of Santa Maria del Campo; shortly afterwards, the first chapel dedicated to the Virgin Mary was built. After being closed in 1742, the building fell into a state of neglect and was demolished in 1790. After several attempts to reinstall the sanctuary, the church was redesigned in its present form on 19 June 1983 and completed on 28 July 1985.

The first church of San Geremia was built between the 7th and 10th centuries and then rebuilt several times. The first reconstruction took place during the reign of Doge Sebastian Ziani (1172-1178). A plaque, which still exists today, embedded near the main door indicates 1292 as the year of the church's consecration. The present building dates from 1753, designed by Carlo Corbellini, and the façade is from 1861. The brick bell tower (probably from the 11th century) has two narrow Romanesque mullioned windows at its base.

The municipal sanctuary of Our Lady of Montalto was founded in 1294, during the long Vespers War (1282-1302). It was maintained for about six centuries until it was abolished in 1866 by the Cistercian nuns. The sanctuary was completely destroyed by the catastrophic earthquake of 1908 and subsequently rebuilt.

The Sanctuary of Nostra Signora della Guardia was built between 1926 and 1931 by order of Don Luigi Orione on the site of the church of the Madonna delle Grazie in 1000, which was run by the Benedictines and later the Franciscans. In 1418, Bernardino of Siena, who gave his name to the village, preached in front of the church. In 1585, a four-sided "pillar" or tabernacle was built on the site of the original church, which was in an advanced state of decay. In the 17th century, a larger sanctuary was built around the "pillar". In 1662, the Franciscans were replaced by the Augustinians, until 1802, when they were suppressed by Napoleon.

The Sanctuary of Nostra Signora di Montallegro, built in the mid-sixteenth century, is a Marian sanctuary that commemorates an apparition of the Virgin Mary in 1557. The construction and management work was entrusted to the master Tommasino Lagomaggiore, an initial project with a single nave, with a marble facade much more varied than the present one. The current marble façade is the work of the architect Luigi Rovelli, and was solemnly inaugurated on 21 June 1896.

The church of San Francesco di Paola and the adjoining convent of the Ordine dei Minimi is a religious complex built between 1464 and 1467. In the 17th century, the religious complex received Baroque additions, probably during the restoration work carried out at the time of two disastrous earthquakes (1613 and 1638). After the Val di Noto earthquake in 1693, the restoration work on the church gave it a late Baroque (Sicilian Baroque) style like most of the buildings in the town. The temple was burnt down on 10 May 1908 and damaged by the Messina earthquake on 28 December of the same year.

The Sanctuary of San Vito began to be built around the 14th century, as a small chapel dedicated to St Vitus the Martyr. The temple was enriched with the proceeds of indulgences granted by Pope Innocent VIII in 1485. In 1526, the entire complex benefited from the munificence of Emperor Charles V of Habsburg. Raised to the rank of sacramental church in 1667 by Monsignor Giuseppe Cigala, Bishop of Mazara, for the assistance of pilgrims in danger of death, it was finally erected as a parish in 1854 by Vincenzo Ciccolo Rinaldi, before the new diocese, in the nascent town of San Vito Lo Capo.

The Santuario di Santa Caterina stands on the birthplace of Catherine of Siena (14th century). The sanctuary includes the Hall of the Saints (Camera della santa), the church Chiesa del Crocifisso (consecrated on 23 April 1623), the sacristy, and the oratories: Oratorio di Santa Caterina, Oratorio della Tintoria (built between 1466 and 1474), and Oratorio della Cucina.

The Sanctuary of Santa Maria del Canneto is a Baroque church that was built in the second half of the 17th century on a pre-existing sacred building dating from 1504. A first church had been built here in the 13th and 14th centuries and was destroyed in 1502 after the French siege. The interior of the present church is divided into three naves. The precious wooden coffered ceiling has a gilded icon of the Virgin Mary in the centre, while a large archway with floral motifs leads to the presbytery.