First mentioned in 1192, the church of San Macuto has had several owners at different times. The monks of Bergamo, who owned the church in the 16th century, gave it a new facade around 1560. The facade was designed by the architect Giovanni Alberto Galvani and was partially rebuilt in 1577-1585 to a design by Francesco da Volterra.
The Baroque church of St. Ignatius stands on the square of the same name and was built by Cardinal Ludovisi in 1626 in honor of St. Ignatius Loyola, founder of the Society of Jesus. The church was built next to the Collegio Romano Palace and replaced the church of S. Maria Annunziata from the 16th century. The church houses the tomb of Pope Gregory XV.
The first mention of the church of Santa Maria in Aquiro dates back to its restoration by Pope Gregory III (731-741). In the 16th century, it was entrusted to the Confraternity of Orphans and was rebuilt in Renaissance style and enlarged around 1590 by Cardinal Anton Maria Salviati. The façade was completed in 1774 by Pietro Camporese. Between 1861 and 1866 the church was completely restored by the architect Gaetano Morichini.
The Basilica Santa Maria Sopra Minerva is a 15th century basilica near the Pantheon. It is a rare example of Gothic architecture in Rome. It is in the contiguous convent of the church that, on June 22, 1633, Galileo Galilei, suspected of heresy, abjured his scientific theses.
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