The church of San Sisto was built from 1490 to 1511 on a former church belonging to a monastery of Benedictine women, which was founded in the 9th century. At the end of the 15th century, the church was demolished in order to build the new temple. The facade was completed only in 1591, and was remodelled in its present classical style in 1755. The monastery was abolished in 1810 and transformed into barracks, while the church became a parish church.
The Cathedral of Piacenza, built between 1122 and 1233, is an important example of Romanesque architecture in Italy. The bell tower is a later work, dating from the 14th century. The modifications made to the cathedral were destroyed during the restoration carried out between 1897 and 1902 by the Bishop of Piacenza Giovanni Battista Scalabrini (1839-1905).
The Basilica of Sant'Antonino was founded in the 4th century and preserves the relics of Antoninus of Piacenza, the patron saint of the town. It is an example of Romanesque architecture and is characterised by a large octagonal tower. The basilica welcomed the delegates of the Lombard League and Emperor Frederick Barbarossa, who gathered there to sign the preliminaries of the Peace of Constance (1183).
The Basilica of Santa Maria di Campagna is a Renaissance church built between 1522 and 1528. The present church was built to replace an old small oratory. The structure of the church was only modified in 1791, with the extension of the arm of the cross which houses the presbytery, and the construction of the present choir behind the high altar. The church houses many works of art, including several early 16th-century Mannerist paintings by Pordenone, and Baroque paintings by Guido Reni and the Procaccini family.
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