Chiesa di San Rocco

The present cathedral of Sansepolcro was built on the site of a former abbey church built around the 11th century for a first Benedictine monastery, which passed to the Camaldolese congregation in the 11th century. It was restored in the 14th century and several times thereafter. The church did not become a cathedral until 1520.

The church of San Francesco Saverio was built between 1680 and 1690 with the adjacent Jesuit college. The design of the church and college was carried out by the Jesuit architect Ciriaco Pichi from Sansepolcro, who also designed the church of Sant'Ignazio in Arezzo. In 1725, the whole building suffered some damage during an earthquake. In 1773, when the Society of Jesus was abolished, the public schools and the episcopal seminary of Sansepolcro were established in the college building. The building now houses the Art School of Sansepolcro.

The church of Sant'Antonio abate was built in 1345 by the Compagnia di Sant'Antonio abate and, founded with the aim of giving shelter and hospitality to the sick and pilgrims, it was annexed to an Oratory and a Hospital. The architectural features of the 14th century have been preserved in the façade, in the ogival portal of Umbrian ambitus which contains a bas-relief dating from 1350. The interior, decorated with 18th-century stucco, contains altars and paintings of the 17th century.